TABLE 6

Antitrypanosomal activities of quinolines in a mouse model of T. b. rhodesiense STIB900 infection

Compound% parasite reduction after treatment with 3 doses of 40 mg/kg i.p.No. of mice cured with 4 doses of 50 mg/kg i.p./no. of mice testedb
1 day3 days
Pentamidinea1001004/4a
100100
DB2104>98>98NT
>98>98
DB2131>981000/4
98>98
DB2161>981000/4
>98>98
DB2171>98990/4
>98>98
DB2186100>982/4
100>98
DB2187>981000/4
98>98
DB2191>98>98NT
>98>98
DB2192>98>98NT
>98>98
DB2212>98>98NT
>98>98
DB2217>98>984/4
>98100
  • a Pentamidine was tested at 3 doses of 4 mg/kg i.p. and at 4 doses of 1 mg/kg i.p. and cured all infected mice.

  • b NT, not tested.