TABLE 1

PK/PD model parameters for AUC/MIC of aerosolized colistin in the ELF and plasma against A. baumannii and K. pneumoniaee

StrainEmaxa (log10 CFU/lung)E0b (log10 CFU/lung)EI50cγdR2
A. baumannii
    AUCELF/MIC
        ATCC 196062.51 (15)7.70 (3.0)628 (8.1)10 (65)0.61
        248-01-C.2485.21 (9.3)8.45 (2.8)490 (7.3)3.5 (27)0.89
        N-16870.2135.80 (22)7.96 (5.9)1419 (13)5.0 (55)0.76
    fAUCplasma/MIC
        ATCC 196062.65 (13)7.83 (2.7)1.94 (9.3)10 (53)0.70
        248-01-C.2485.17 (9.6)8.44 (2.8)1.40 (9.0)2.85 (29)0.89
        N-16870.2137.16 (48)8.20 (6.2)5.12 (52)2.04 (62)0.77
K. pneumoniae
    AUCELF/MIC
        ATCC BAA 21462.84 (31)8.97 (4.6)421 (33)2.12 (72)0.64
        173.22 (12)8.45 (3.2)554 (5.3)10 (59)0.76
        KP13.49 (22)9.90 (4.55)1581 (22)2.38 (49)0.68
    fAUCplasma/MIC
        ATCC BAA 21462.94 (24)8.98 (4.9)1.10 (29)2.0 (59)0.63
        173.19 (12)8.40 (3.1)1.62 (5.4)10 (94)0.77
        KP13.50 (23)9.90 (4.5)4.40 (26)2.0 (50)0.68
  • a Emax is the maximal effect.

  • b E0 is the effect without colistin treatment.

  • c EI50 is the value of AUC/MIC required to achieve 50% of Emax.

  • d γ is the Hill coefficient.

  • e Data in parentheses are the percentage relative standard error (%RSE).