TABLE 2

Targets of AUCELF/MIC and fAUCplasma/MIC associated with bacteriostasis and 1- and 2-log10 kills against A. baumannii and K. pneumoniae in neutropenic infected mice after aerosolized colistin

StrainAUC/MIC target (10th–90th percentiles)
Stasis1-log10 kill2-log10 kill
A. baumannii
    AUCELF/MIC
        ATCC 19606364 (270–568)604 (506–681)722 (629–1,040)
        248-01-C.248326 (248–386)430 (366–491)540 (464–650)
        N-16870.213989 (536–1,268)1,213 (882–1,496)1,404 (1,116–1,846)
    fAUCplasma/MIC
        ATCC 196061.45 (1.11–1.80)1.88 (1.63–2.15)2.24 (1.91–2.77)
        248-01-C.2480.86 (0.52–1.04)1.20 (1.00–1.44)1.58 (1.37–1.96)
        N-16870.2132.18 (0.40–4.70)3.29 (1.03–7.37)4.45 (1.66–11.8)
K. pneumoniae
    AUCELF/MIC
        ATCC BAA 2146527 (294–1,766)NDaND
        17525 (451–577)597 (533–727)866 (583–896)
        KP12,924 (1,567–6,552)NDND
    fAUCplasma/MIC
        ATCC BAA 21461.34 (0.69–3.87)NDND
        171.53 (1.21–1.66)1.74 (1.59–2.33)2.44 (1.73–4.28)
        KP16.62 (3.65–18.0)NDND
  • a ND, not determined.