TABLE 5

Antitrypanosomal activities of quinolines in mouse models of T. cruzi infection (Y strain) using 25 mg/kg (i.p.) for five consecutive days starting at parasitemia onset (5 dpi)

CompoundMouse gender% parasite variation at parasitemia peak (8 dpi)% cumulative mortality at 30 days posttherapy
BenznidazoleaFemale1000
Male1000
VehicleFemale050
Male083
DB2187bMale−38100
DB2186Female−2575
Male−7050
DB2191Female−950
Male−27100
DB2192Female+7433
Male+28100
  • a Benznidazole was tested at 100 mg/kg p.o.

  • b DB2187 was tested at 20 mg/kg i.p. at 5 and 8 dpi.