TABLE 2

Genetic mutations and antibiotic susceptibilities of A. baumannii sulbactam-ETX2514-resistant mutants

Isolate and variantProtein affectedMIC (μg/ml)a
SUL-ETX2514SULETX2514MEMCAZ
ARC2058
    Parent14640.54
    2X-1AspS (Q27P)164>641616
    2X-2GltX (M240I)164>6484
    2X-3GltX (R117S)644>64328
    2XL-1PBP3 (V505L)1616>640.254
ARC2681
    Parent286432256
    4X-1PBP3 (S390T)>64>64>6432128
ARC2782
    Parent0.5323216>512
    2X-1PBP3 (T511A)464>6416>512
  • a SUL-ETX2514, sulbactam in the presence of ETX2514 at a fixed concentration of 4 μg/ml; SUL, sulbactam alone; ETX2514, ETX2514 alone; MEM, meropenem; CAZ, ceftazidime.