TABLE 2

Susceptibility profiles of Enterobacteriaceae isolates collected from hospitalized patients with pneumonia in U.S. hospitals

Organism or organism group (no. tested)% susceptibility using CLSI interpretative criteria
Ceftolozane-tazobactamCeftazidimeCefepimeMeropenemPiperacillin-tazobactamAmikacinColistinaLevofloxacinTigecyclineb
Enterobacteriaceae (2,362)90.684.088.295.686.198.075.184.298.5
    Escherichia coli (441)98.085.985.099.890.499.599.560.2100.0
    Klebsiella pneumoniae (627)85.877.578.688.781.793.896.882.599.0
    Klebsiella oxytoca (190)97.497.497.498.988.9100.0100.098.9100.0
    Enterobacter cloacae (270)83.374.490.098.981.099.679.696.399.6
    Enterobacter aerogenes (161)90.178.998.198.881.299.496.397.599.4
    Citrobacter koseri (42)100.0100.0100.0100.0100.0100.0100.092.9100.0
    Citrobacter freundii (32)68.862.587.596.971.9100.096.996.9100.0
    Proteus mirabilis (90)98.998.996.798.9100.0100.00.067.875.6
    Indole-positive Proteeae (46)95.789.193.5100.097.8100.00.069.693.5
    Serratia spp. (354)94.495.295.296.990.799.25.195.299.7
    Isolates carrying ESBL genes (145)82.820.015.297.974.393.897.229.097.9
        Isolates carrying blaCTX-M (111)88.323.44.598.277.395.598.222.597.3
            Isolates carrying blaCTX-M-15-like genes (89)85.49.01.197.871.694.497.825.896.6
            Isolates carrying blaCTX-M-14-like genes (22)100.081.818.2100.0100.0100.0100.09.1100.0
        Isolates carrying blaSHV ESBL (31)61.36.551.696.861.387.193.554.8100.0
        Isolates carrying blaTEM ESBL (3)100.033.333.3100.0100.0100.0100.00.0100.0
    Isolates carrying blaKPC (70)1.40.01.42.90.054.385.38.6100.0
    Isolates carrying transferable AmpC genes (13)84.67.784.6100.061.5100.0100.053.8100.0
  • a EUCAST breakpoints were applied for colistin.

  • b FDA package insert breakpoints were applied for tigecycline.