TABLE 1

Summary of microbiological activity of APX001A and comparators against 16 strains of C. auris

Antifungal agentTreatment period (h)MIC (μg/ml)a
RangeMIC50MIC90
APX001A240.002–0.0630.0040.031
5FC480.5–10.51
AFG240.125–0.250.1250.25
CAS240.25–10.51
MFG240.25–212
AMB240.5–824
482–848
FLC241–>6416>64
482–>64>64>64
ITC48<0.063–10.51
POS480.25–10.251
VRC24<0.063–10.51
48<0.063–20.52
  • a MIC values were read at either 50 or 100% inhibition as indicated by CLSI; APX001A was read at 50% inhibition and at 24 h as previously determined.