TABLE 5

Drug-drug interaction analysis

ParameterANOVA model applied to meropenem PK parametersaANOVA model applied to vaborbactam PK parametersb
Meropenem aloneCombinationVaborbactam aloneCombination
Cmax (μg/ml)
    LS geometric mean21.623.222.824.1
    LS geometric mean (90% CI)19.1, 24.320.6, 26.117.5, 29.618.5, 31.4
    LS geometric mean ratio1.071.06
    LS geometric mean ratio (90% CI)1.01, 1.141.01, 1.11
AUC0–t (μg · h/ml)
    LS geometric mean65.571.273.678.8
    LS geometric mean (90% CI)58.1, 73.463.2, 80.256.5, 95.960.5, 103
    LS geometric mean ratio1.091.07
    LS geometric mean ratio (90% CI)1.04, 1.131.04, 1.11
AUC0–inf (μg · h/ml)
    LS geometric mean66.071.974.679.9
    LS geometric mean (90% CI)58.6, 74.463.8, 81.157.4, 96.961.5, 104
    LS geometric mean ratio1.091.07
    LS geometric mean ratio (90% CI)1.05, 1.141.04, 1.11
  • a Only those subjects who crossed over from single-dose meropenem to single-dose combination treatment are included in this analysis (n = 35).

  • b Only those subjects who crossed over from single-dose vaborbactam to single-dose combination treatment are included in this analysis (n = 35).