TABLE 2

Static doses and associated AUC/MIC values in the neutropenic disseminated candidiasis modela

SpeciesIsolate or parameterLog10 no. of CFU/kidneysED50Stasis
StartGrowthMaximum kill24-h dose (mg/kg)24-h tAUC/MIC24-h fAUC/MIC24-h dose (mg/kg)24-h tAUC/MIC24-h fAUC/MIC
C. albicansK14.163.40−1.3787.33,4136.83265.512,95225.91
98-2103.364.050.9943.13710.742NA
5804.243.09−0.9351.33,3616.7286.06,67813.35
2-763.543.78−1.5417.71,9994.0076.511,27022.54
98-174.392.900.115.7141.90.084NA
Mean3.943.44−0.5541.01,8373.67142.510,30020.60
Median4.163.40−0.9343.11,9994.0086.011,27022.54
SD0.460.481.0731.81,5973.19106.73,2486.50
C. glabrata109563.853.64−1.224.7650.1328.1432.80.866
55923.913.13−0.7229.91240.247125.2734.21.47
353154.073.15−1.4120.93070.6141.9675.51.35
5133.863.56−1.1522.51780.3669.4647.21.29
53764.173.15−1.6210.32284.10.56826.0792.31.59
Mean3.973.33−1.2217.71920.3858.1656.41.31
Median3.913.15−1.2220.91780.3641.9675.51.35
SD0.140.250.3410.11030.2141.3136.90.27
C. aurisB111044.183.310.2124.8682.01.36NA
B112214.323.24−0.9447.53,095.16.19100.24,213.08.25
B112194.312.36−0.99106.44,469.28.9478.65,864.211.73
B118044.183.46−1.02671.36,034.512.07243.312,02224.04
Mean4.253.09−0.69212.53,570.27.14140.77,336.414.67
Median4.253.28−0.9777.03,782.27.56100.25,864.211.73
SD0.080.500.60307.82,269.24.5489.54,150.28.30
  • a NA, not achieved; tAUC, total drug AUC; fAUC, free (non-protein-bound) drug AUC.