TABLE 3

Meropenem urine PK parameters

Cohort/dosea and treatmentnMedian (range) amt (mg) excreted as intact meropenemMedian (range) % of dose excreted as intact meropenemMedian (range) renal clearance (liter/h)
Single dose (collected over 48 h)Multiple dose (collected over 24 h)Single dose (collected over 48 h)Multiple dose (collected over 24 h)Single doseMultiple dose
1/1,000:250
    Meropenem alone32562.8 (358.1–687.4)603.5 (503.6–710.8)56.3 (35.8–68.7)60.4 (50.4–71.1)11.4 (5.4–14.9)12.6 (8.7–17.9)
    Combination16608.8 (521.3–695.6)635.5 (458.4–1299)60.9 (52.1–69.6)63.6 (45.8–129.9)10.5 (8.7–13.1)13.5 (10.1–28.0)
2/1,000:1,000
    Meropenem alone13534.4 (421.8–613.7)545.7 (462.2–629.3)53.4 (42.2–61.4)54.6 (46.2–62.9)8.9 (6.8–11.1)10.8 (10.2–11.3)
    Combination10529.4 (437.3–581.2)537.8 (423.4–685.4)52.9 (43.7–58.1)53.8 (42.3–68.5)8.1 (6.6–9.7)10.4 (8.6–10.8)
3/1,000:1,500
    Meropenem alone19558.4 (470.9–619.6)606.1 (600.5–611.9)55.8 (47.1–62.0)60.6 (60.1–61.2)8.5 (6.7–10.2)10.1 (6.6–11.0)
    Combination14499.7 (346.4–650.1)538.6 (376.9–888.5)50.0 (34.6–65.0)53.9 (37.7–88.8)6.9 (4.6–11.4)8.7 (5.5–14.5)
4/1,000:2,000
    Meropenem alone19563.4 (409.2–734.9)564.6 (540.7–602.8)56.3 (40.9–73.5)56.5 (54.1–60.3)10.9 (6.8–15.1)11.2 (9.8–12.4)
    Combination14486.6 (384.9–567.4)512.4 (88.9–645.9)48.7 (38.5–56.7)51.2 (8.9–64.6)8.6 (7.0–11.6)10.5 (1.9–14.1)
5/2,000:2,000
    Meropenem alone201,069 (723.0–1,345)1,084 (913.5–1,343)53.4 (36.2–67.2)54.2 (45.7–67.2)8.0 (4.6–11.9)8.9 (6.1–10.0)
    Combination16937.8 (844.8–1,191)1,120 (829.4–1,202)46.9 (42.2–59.6)56.0 (41.50–60.1)6.9 (5.2–8.9)8.1 (5.8–9.4)
  • a Expressed as meropenem (mg): vaborbactam (mg).