TABLE 2

Anidulafungin pharmacokinetics in ascites fluid and pleural effusion with 24-h samplinga

SamplePatientCmax (μg/ml)Tmax (h)AUC0–24 (μg · h/ml)t1/2 (h)PR
Ascites fluid20.98417.5260.37
30.34127.01620.07
Plasma23.82147.225
37.70193.830
Pleural effusion90.99421.43620.18
Plasma98.831116.536
  • a Cmax, anidulafungin maximum concentration; Tmax, time to Cmax; AUC0–24, area under the concentration-time curve from the start of the anidulafungin infusion to the last sampling, which was at 24 h; t1/2 anidulafungin half-life; PR, penetration ratio, specifically, AUC0–24 ascites fluid/AUC0–24 plasma for ascites fluid and AUC0–24 pleural effusion/AUC0–24 plasma for pleural effusion.