TABLE 4

Vaborbactam urine PK parameters

Cohort/dosea and treatmentnMedian (range) amt (mg) excreted as intact vaborbactamMedian (range) % of dose excreted as intact vaborbactamMedian (range) renal clearance (liter/h)
Single dose (collected over 48 h)Multiple dose (collected over 24 h)Single dose (collected over 48 h)Multiple dose (collected over 24 h)Single doseMultiple dose
1/1,000:250
    Vaborbactam alone40206.2 (124.3–356.5)219.1 (49.3–256.6)82.5 (49.7–142.6)87.6 (19.7–102.6)12.2 (6.3–23.7)13.1 (3.3–19.7)
    Combination16212.1 (200.1–2,824)231.1 (196.9–588.2)84.84 (80.0–1,130)95.2 (78.8–235.3)11.8 (10.1–189.8)17.6 (12.5–44.9)
2/1,000:1,000
    Vaborbactam alone5810.0 (789.7–922.2)81.0 (79.0–92.2)11.0 (8.8–14.9)
    Combination10830.9 (773.4–682.5)858.2 (757.9–930.3)83.1 (77.3–86.3)85.8 (75.8–93.0)10.3 (8.6–12.7)11.5 (10.6–16.1)
3/1,000:1,500
    Vaborbactam alone71,233 (1,010–1,400)82.2 (67.3–93.3)9.8 (8.5–14.0)
    Combination141,128 (858.9–1,324)1,284 (1,015–1,728)75.2 (57.3–88.3)85.6 (67.6–115.2)8.6 (6.8–11.0)12.3 (8.5–15.6)
4/1,000:2,000
    Vaborbactam alone71,744 (1,591–1,825)87.2 (79.6–91.3)14.1 (12.2–15.4)
    Combination141,718 (1,341–1,781)1,697 (318.9–1,821)85.9 (67.1–89.1)84.8 (16.0–91.1)12.6 (10.5–15.3)13.9 (2.8–18.5)
5/2,000:2,000
    Vaborbactam alone81,785 (1,347–2,070)89.3 (67.4–103.5)10.8 (8.6–14.4)
    Combination161,548 (1,388–1,622)1,715 (1,502–1,926)77.4 (69.4–81.1)85.8 (75.1–96.3)10.0 (6.9–11.4)8.6 (6.5–12.1)
  • a Expressed as meropenem (mg): vaborbactam (mg).