Model | V (liters)_{c} | CL (liters/h) | V (liters)_{p} | Q (liters/h) | AIC | R^{2} |
---|---|---|---|---|---|---|

One compartment | 12.9 ± 2.48 | 1.58 ± 0.247 | NA | NA | 2,478 | 0.806 |

Two compartment | 6.70 ± 1.57 | 1.57 ± 0.255 | 7.53 ± 1.75 | 7.24 ± 2.18 | 2,012 | 0.882 |

Two compartment^{b} | 6.40 ± 1.10 | 1.57 ± 0.252 | 7.20 ± 1.35 | 6.88 ± 1.18 | 1,957 | 0.941 |

↵a Values are reported as means ± standard deviations. Abbreviations:

*V*, volume of distribution in the central compartment; CL, total body clearance;_{c}*V*, volume of distribution in the peripheral compartment;_{p}*Q*, intercompartmental clearance; AIC, Akaike information criterion;*R*^{2}, coefficient of determination for the observed versus population predicted values.↵b Final covariate structured model for

*V*,_{c}*V*, and_{p}*Q*as a linear function of adjusted body weight with values scaled to an 80-kg individual.