TABLE 1

In vitro susceptibilities of the Corynebacterium isolates received at the PHOL from 2011 to 2016

Antimicrobial agent by organismNo. of isolatesMIC rangeMIC50MIC90% Sa
All Corynebacterium spp.1,970
    Penicillin1,970≤0.06 to >84>814.5
    Ampicillin1,969≤0.12 to >82>8ND
    Oxacillin1,969≤0.25 to >4>4>4ND
    Erythromycin1,970≤0.25 to >4>4>415.1
    Clindamycin1,958≤0.5 to >2>2>28.7
    Ciprofloxacin1,959≤1 to >2>2>226.9
    Levofloxacin1,968≤0.25 to >4>4>4ND
    Moxifloxacinb1,968≤0.25 to >4>4>427.7
    Tetracycline1,969≤2 to >16≤2>1664.2
    Vancomycin1,970≤0.25 to 20.50.5100
    Trimethoprim-sulfamethoxazole1,967≤0.5 to >44>438.1
    Tigecycline1,967≤0.03 to >0.50.120.25ND
    Rifampin1,968≤0.5 to>4≤0.5≤0.591.4
    Quinupristin-dalfopristin1,969≤0.5 to >4≤0.5193.3
    Linezolid1,969≤1 to 2≤1≤1100
    Gentamicin1,970≤2 to >16≤2493.3
    Daptomycin1,959≤0.5 to >4≤0.5≤0.597.7
    Chloramphenicol1,960≤2 to >164>16ND
    Nitrofurantoin1,969≤32 to >64>64>64ND
C. striatum931
    Penicillin931≤0.06 to >88>80.1
    Ampicillin930≤0.12 to >84>8ND
    Oxacillin930≤0.25 to >4>4>4ND
    Erythromycin931≤0.25to >4>4>414.6
    Clindamycin922≤0.5 to >2>2>25.4
    Ciprofloxacin926≤1 to >2>2>24.6
    Levofloxacin930≤0.25 to >4>4>4ND
    Moxifloxacinb929≤0.25 to >4>4>45.2
    Tetracycline930≤2 to >16>16>1634.7
    Vancomycin931≤0.25 to 10.50.5100
    Trimethoprim-sulfamethoxazole928≤0.5 to >4>4>411.5
    Tigecycline929≤0.03 to >0.50.120.25ND
    Rifampin930≤0.5 to >4≤0.5>485.6
    Quinupristin-dalfopristin930≤0.5 to 2≤0.5≤0.599.4
    Linezolid930≤1≤1≤1100
    Gentamicin931≤2 to >16≤2492.8
    Daptomycin924≤0.5 to>4≤0.5≤0.598
    Chloramphenicol924≤2 to >16≤216ND
    Nitrofurantoin930≤32 to >64>64>64ND
C. amycolatum190
    Penicillin190≤0.06 to >81>810.5
    Ampicillin190≤0.12 to >81>8ND
    Oxacillin190≤0.25 to >4>4>4ND
    Erythromycin190≤0.25 to >4>4>415.8
    Clindamycin189≤0.5 to>2>2>220.5
    Ciprofloxacin189≤1 to >2>2>226.8
    Levofloxacin190≤0.25 to >4>4>4ND
    Moxifloxacinb190≤0.25 to >44>427.4
    Tetracycline190≤2 to >16≤21685.8
    Vancomycin190≤0.25 to 10.50.5100
    Trimethoprim-sulfamethoxazole190≤0.5 to >41>466.8
    Tigecycline189≤0.03 to >0.50.120.25ND
    Rifampin190≤0.5 to >4≤0.5≤0.598.4
    Quinupristin-dalfopristin190≤0.5 to 2≤0.5≤0.599.5
    Linezolid190≤1≤1≤1100
    Gentamicin190≤2 to >16≤2493.2
    Daptomycin190≤0.5 to 2≤0.5≤0.599.5
    Chloramphenicol189≤2 to >16≤216ND
    Nitrofurantoin190≤32 to >64>64>64ND
C. pseudodiphtheriticum/C. propinquum216
    Penicillin216≤0.06 to 4≤0.06≤0.0695.8
    Ampicillin216≤0.12 to 4≤0.12≤0.12ND
    Oxacillin216≤0.25 to >40.51ND
    Erythromycin216≤0.25 to >4>4>421.3
    Clindamycin216≤0.5 to >2>2>220.8
    Ciprofloxacin216≤1 to >2≤1>278.7
    Levofloxacin216≤0.25 to >41>4ND
    Moxifloxacinb216≤0.25 to >4≤0.25>479.2
    Tetracycline216≤2 to >16≤2≤298.6
    Vancomycin216≤0.25 to 20.50.5100
    Trimethoprim-sulfamethoxazole216≤0.5 to >4≤0.5487.5
    Tigecycline216≤0.03 to >0.50.060.25ND
    Rifampin216≤0.5 to 1≤0.5≤0.5100
    Quinupristin-dalfopristin216≤0.5 to 1≤0.5≤0.5100
    Linezolid216≤1 to 2≤1≤1100
    Gentamicin216≤2≤2≤2100
    Daptomycin216≤0.5 to >4≤0.5≤0.599.5
    Chloramphenicol216≤2 to >164>16ND
    Nitrofurantoin216≤32 to >64>64>64ND
C. afermentans subsp. afermentans89
    Penicillin89≤0.06 to >84>81.12
    Ampicillin89≤0.12 to >848ND
    Oxacillin89≤0.25 to >4>4>4ND
    Erythromycin892 to >4>4>40
    Clindamycin891 to >2>2>20
    Ciprofloxacin89≤1 to >2>2>230.3
    Levofloxacin89≤0.25 to >4>4>4ND
    Moxifloxacinb89≤0.25 to >4>4>431.5
    Tetracycline89≤2 to >16≤2887.6
    Vancomycin89≤0.25 to 1≤0.250.50100
    Trimethoprim-sulfamethoxazole89≤0.5 to>42>455.1
    Tigecycline89≤0.03 to >0.50.120.25ND
    Rifampin89≤0.5 to >4≤0.5≤0.594.4
    Quinupristin-dalfopristin89≤0.5 to >41451.7
    Linezolid89≤1 to 2≤1≤1100
    Gentamicin89≤2 to >16≤2≤298.9
    Daptomycin89≤0.5 to 4≤0.5≤0.597.8
    Chloramphenicol89≤2 to >168>16ND
    Nitrofurantoin89≤32 to >64>64>64ND
C. jeikeium76
    Penicillin760.5 to >8>8>80
    Ampicillin76≤0.12 to >8>8>8ND
    Oxacillin760.5 to >4>4>4ND
    Erythromycin76≤0.25 to >4>4>411.8
    Clindamycin76≤0.5 to >2>2>22.6
    Ciprofloxacin75≤1 to >2>2>235.5
    Levofloxacin75≤0.25 to >4>4>4ND
    Moxifloxacinb76≤0.25 to >44>435.5
    Tetracycline76≤2 to >16≤2≤292.1
    Vancomycin76≤0.25 to 20.501100
    Trimethoprim-sulfamethoxazole76≤0.5 to >4>4>418.4
    Tigecycline76≤0.03 to >0.50.120.25ND
    Rifampin76≤0.5 to >4≤0.5≤0.597.4
    Quinupristin-dalfopristin76≤0.5 to 4≤0.5289.5
    Linezolid76≤1≤1≤1100
    Gentamicin76≤2 to >16≤2>1681.6
    Daptomycin75≤0.5 to >4≤0.5189.5
    Chloramphenicol75≤2 to >16416ND
    Nitrofurantoin76≤32 to >64>64>64ND
C. minutissimum76
    Penicillin76≤0.06 to >8183.9
    Ampicillin76≤0.12 to >814ND
    Oxacillin762 to >4>4>4ND
    Erythromycin76≤0.25 to >4>4>419.7
    Clindamycin76≤0.5 to >2>2>21.3
    Ciprofloxacin74≤1 to >2≤1>255.3
    Levofloxacin76≤0.25 to >4≤0.25>4ND
    Moxifloxacinb76≤0.25 to >4≤0.25>461.8
    Tetracycline76≤2 to >16≤2492.1
    Vancomycin76≤0.25 to 10.500.50100
    Trimethoprim-sulfamethoxazole76≤0.5 to >42>461.8
    Tigecycline76≤0.03 to >0.50.060.25ND
    Rifampin75≤0.5 to >4≤0.5≤0.596.1
    Quinupristin-dalfopristin76≤0.5 to 4≤0.5193.4
    Linezolid76≤1 to >8≤1≤198.7
    Gentamicin76≤2 to >16≤2≤296.1
    Daptomycin75≤0.5 to >4≤0.5192.1
    Chloramphenicol75≤2 to >1648ND
    Nitrofurantoin76≤32 to >6464>64ND
C. coyleae58
    Penicillin58≤0.06 to >84>81.7
    Ampicillin58≤0.12 to >848ND
    Oxacillin582 to >4>4>4ND
    Erythromycin58≤0.25 to >4>4>43.5
    Clindamycin58≤0.5 to >2>2>23.5
    Ciprofloxacin57≤1 to >2>2>227.6
    Levofloxacin58≤0.25 to >4>4>4ND
    Moxifloxacinb58≤0.25 to >44>429.3
    Tetracycline58≤2 to >16≤2≤293.1
    Vancomycin58≤0.25 to 20.50.50100
    Trimethoprim-sulfamethoxazole58≤0.5 to >44>448.3
    Tigecycline58≤0.03 to >0.50.060.25ND
    Rifampin58≤0.5 to >4≤0.5≤0.591.4
    Quinupristin-dalfopristin58≤0.5 to 42443.1
    Linezolid58≤1 to 2≤1≤1100
    Gentamicin58≤2≤2≤2100
    Daptomycin57≤0.5 to >4≤0.5≤0.593
    Chloramphenicol58≤2 to >164>16ND
    Nitrofurantoin58≤32 to >64>64>64ND
C. urealyticum52
    Penicillin520.12 to >8>8>83.8
    Ampicillin52≤0.12 to >8>8>8ND
    Oxacillin521 to >4>4>4ND
    Erythromycin52≤0.25 to >4>4>41.9
    Clindamycin51≤0.5 to >2>2>23.8
    Ciprofloxacin51≤1 to >2>2>23.8
    Levofloxacin52≤0.25 to >4>4>4ND
    Moxifloxacinb52≤0.25 to >4>4>43.8
    Tetracycline52≤2 to >16≤2≤292.3
    Vancomycin52≤0.25 to 20.501100
    Trimethoprim-sulfamethoxazole52≤0.5 to >4>4>41.9
    Tigecycline52≤0.03 to >0.50.060.12ND
    Rifampin52≤0.5 to >4≤0.5≤0.592.3
    Quinupristin-dalfopristin52≤0.5 to 1≤0.5≤0.5100
    Linezolid52≤1≤1≤1100
    Gentamicin52≤2 to >16≤2>1655.7
    Daptomycin51≤0.5≤0.5≤0.5100
    Chloramphenicol52≤2 to >168>16ND
    Nitrofurantoin52>64>64>64ND
C. aurimucosum51
    Penicillin510.12 to >81>85.8
    Ampicillin510.25 to >818ND
    Oxacillin512 to >4>4>4ND
    Erythromycin51≤0.25 to >4>4>411.7
    Clindamycin511 to >2>2>20
    Ciprofloxacin51≤1 to >2>2>243.1
    Levofloxacin51≤0.25 to >44>4ND
    Moxifloxacinb51≤0.25 to >42>443.1
    Tetracycline51≤2 to >16≤2490.2
    Vancomycin51≤0.25 to 10.500.50100
    Trimethoprim-sulfamethoxazole51≤0.5 to >42>462.7
    Tigecycline51≤0.03 to 0.250.060.12ND
    Rifampin51≤0.5≤0.5≤0.5100
    Quinupristin-dalfopristin51≤0.5 to 4≤0.5192.2
    Linezolid51≤1≤1≤1100
    Gentamicin51≤2 to 4≤2≤2100
    Daptomycin51≤0.5 to 3≤0.5≤0.598
    Chloramphenicol51≤2 to >1648ND
    Nitrofurantoin51≤32 to >6464>64ND
  • a % S, percentage of susceptible isolates; ND, not determined.

  • b EUCAST breakpoints were applied for moxifloxacin (≤0.5 mg/liter, susceptible; >0.5 mg/liter, resistant).