TABLE 1

Velocity of the reduction of viable counts from uropathogens in urine specimens of uUTI patients, determined in a phase II studya

Ciprofloxacin MIC of isolate (mg/liter)MedicationCFU/ml
Predose2 h4 h8 h
0.008Finafloxacin1.7 × 107
0.012Finafloxacin1.0 × 106
0.012Finafloxacin2.7 × 105
0.19Finafloxacin2.8 × 105
>32Finafloxacin1.5 × 1083.6 × 1062.5 × 104
0.008Ciprofloxacin1.4 × 105
0.012Ciprofloxacin2.3 × 1062.0 × 103
0.19Ciprofloxacin3.4 × 1076.1 × 1042.7 × 103
  • a Viable counts of pathogens isolated from urine specimens of uUTI patients were determined before and 2, 4, and 8 h after treatment with a single oral dose of 250 mg ciprofloxacin or 300 mg finafloxacin. —, no growth was detected.