Parameter | Median value | 95% CI | IIV (%) | IOV (%) |
---|---|---|---|---|

Intravenous data | ||||

CL (liters/h) | 20.9 | 18.5, 23.4 | 54 | 8 |

V_{c} (liters) | 46.9 | 45.1, 49.0 | 20 | 8 |

Q (liters/h) | 2.80 | 2.47, 3.17 | 57 | 18 |

V_{p} (liters) | 43.1 | 37.2, 49.8 | 67 | 22 |

BSA on V_{c} | 1.50 | 0.96, 1.96 | ||

Patient status on CL | −0.29 | −0.38, −0.18 | ||

FER_{1} | 0.40 | 0.38, 0.43 | 19 | |

FER_{2} | 0.21 | 0.17, 0.26 | 62 | |

Additive RUV, plasma | 0.001 | 0.001, 0.002 | ||

Proportional RUV, plasma | 0.24 | 0.22, 0.26 | ||

Additive RUV, urine | 0.001 | 0.001, 0.154 | ||

Proportional RUV, urine | 0.33 | 0.29, 0.36 | ||

Oral data | ||||

F | 0.75 | 0.59, 0.79 | 33 | 32 |

f_{1st} | 0.77 | 0.77, 0.95 | 39 | 36 |

K (h_{a}^{−1}) | 6.61 | 3.19, 6.61 | 33 | 168 |

LAG_{1} (h) | 0.22 | 0.14, 0.24 | 30 | 28 |

D_{0} (h) | 7.77 | 7.39, 12.17 | 31 | 31 |

LAG_{2} (h) | 0.54 | 0.41, 1.13 | 33 | 32 |

Proportional RUV | 0.14 | 0.13, 0.24 | ||

Additive RUV | 0.03 | 0.00, 0.03 |

↵a Median estimates as well as 95% confidence intervals (CIs) of population pharmacokinetic parameters from bootstrap statistics (

*n*= 1,000) based on intravenous (healthy volunteers and patients) and oral (healthy volunteers) data. Shown are percent coefficients of variation for interindividual variability (IIV) and interoccasion variability (IOV). BSA, body surface area (given parameter estimates are exponents of BSA values normalized to a standard individual with a weight of 70 kg and a height of 172 cm); FER, fraction of finafloxacin excreted unchanged renally in healthy volunteers (FER_{1}) and patients (FER_{2});*F*, absolute oral bioavailability;*f*_{1st}, fraction of drug absorbed by a first-order process;*K*, absorption rate constant for a first-order process; LAG_{a}_{1}, lag time for a first-order process;*D*_{0}, duration of a zero-order process; LAG_{2}, lag time of a zero-order process; RUV, residual unexplained variability given a combined additive- and proportional-error model.