TABLE 3

Noncompartmental PK parameters of telavancin in obese and nonobese adult subjectsa

SubgroupCmax (mg/liter)AUC0–∞ (mg · h/liter)CL (liters/h)CLR (liters/h)Vss (liters)t1/2 (h)
Normal to overweight (n = 8)68.0 ± 5.6A469.9 ± 69.0B,C1.34 ± 0.250.99 ± 0.1711.71 ± 2.6B,C6.10 ± 0.6
Obese class I (n = 8)92.0 ± 21.9A551.2 ± 73.81.59 ± 0.181.19 ± 0.1313.04 ± 1.5D5.82 ± 0.5
Obese class II (n = 8)86.7 ± 9.6618.6 ± 70.3B1.63 ± 0.171.25 ± 0.1515.06 ± 2.2B6.38 ± 0.8
Obese class III (n = 8)79.8 ± 13.2612.4 ± 131.1C1.69 ± 0.311.10 ± 0.2216.24 ± 2.7C,D6.68 ± 0.9
  • a Statistically significant differences (P < 0.05) between subgroups are indicated as follows: A, normal to overweight compared to obese class I; B, normal to overweight compared to obese class II; C, normal to overweight compared to obese class III; D, obese class I compared to obese class III. Abbreviations: Cmax, maximum plasma concentration; AUC0–∞, area under the concentration-time curve from time zero to infinity; CL, total body clearance; CLR, renal clearance; Vss, volume of distribution at steady state; t1/2, elimination half-life.