TABLE 4

Anidulafungin concentrations in single samples obtained by paracentesis and thoracentesisa

PatientConcn of anidulafungin (μg/ml) in:Time from infusion (h)Day of anidulafungin treatmentPR
Ascites fluidPleural effusionPlasma
40.282.888.030.10
50.305.395.550.06
60.324.698.820.07
70.452.1518.070.21
70.452.4820.0210.18
90.884.509.540.20
100.324.184.0120.08
  • a Time from infusion, time from the start of the anidulafungin infusion to sampling; PR, penetration ratio obtained from single ascites fluid samples (for patients 4 to 7, we determined the concentration in ascites fluid/concentration in plasma) and pleural effusion samples (for patients 7 to 10, we determined the concentration in pleural effusion/concentration in plasma). Patient 4 underwent paracentesis on day 3 of anidulafungin treatment and ascites fluid drainage on day 7 because of recurrent ascites. Patient 7 underwent paracentesis on day 7 and thoracentesis on day 21 of anidulafungin treatment.