TABLE 3

Pharmacokinetic parameters of lascufloxacin in plasma, ELF, and AMa

SampleTmax (h)Cmax (μg/ml)AUC0–24 (μg · h/ml)Site-to-plasma Cmax ratioSite-to-free plasma Cmax ratioSite-to-plasma AUC0–24 ratioSite-to-free plasma AUC0–24 ratio
Plasma10.5767.67
ELF112.312321.482.116.061.7
AM621.832537.814642.4163
  • a Pharmacokinetic parameters were calculated from the mean concentration-time profile of lascufloxacin. ELF, epithelial lining fluid; AM, alveolar macrophages.