Parameter | Median value for trial (95% prediction interval) | |
---|---|---|

II | III | |

AUC (mg · h/liter) | 38 (15–96) | 54 (22–134) |

AUC^{W} (mg · h/liter) | 39 (15–101) | 53 (19–143) |

C_{max} (mg/liter) | 14 (9–23) | 16 (10–27) |

T_{max} (h) | 1.12 (1.01–1.37) | 1.13 (1.01–1.45) |

T_{1/2} (P) (h) | 1.66 (0.67–4.0) | 2.15 (0.87–5.27) |

T_{1/2} (T) (h) | 12.5 (6.21–25.2) | 13.3 (6.5–27.1) |

↵a Shown are plasma predictions (medians and 95% prediction intervals) of the AUC normalized to a body weight of 75 kg (AUC

^{W}), the maximum attained concentration (*C*_{max}), the time at which the maximum concentration was reached (*T*_{max}), as well as plasma (P) and terminal (T) elimination-half-lives (*T*_{1/2}) given a simulated intravenous administration of 800 mg finafloxacin per day at steady state. Presented values were calculated via a Monte Carlo simulation using covariate data from all healthy volunteers from trial II and data from all patients from trial III.