TABLE 3

Binding of anti-HA stalk-neutralizing MAbs to influenza A and B virus HAs

Influenza A and B virus HAELISA signala
Anti-IBVAnti-IAV
TRL845TRL847TRL848TRL849TRL854TRL053TRL579
IBV Victoria lineage HA
    B/Brisbane/60/2008+++++++++++++++
    B/Malaysia/2506/2004+++++++++++++++
    B/Victoria/2/1987+++++++++++++++
IBV Yamagata lineage HA
    B/Florida/4/2006+++++++++++++++
    B/Massachusetts/02/2012+++++++++++++++
    B/Wisconsin/1/2010+++++++++++++++
IAV (H1N1) group 1 HA
    A/California/07/2009+++
IAV (H3N2) group 2 HA
    A/Sydney/05/1997+++
  • a The ELISA signals are represented as negative (−; i.e., the background level) or strongly positive (+++; i.e., corresponding to 18 to 21 times the background level). Anti-IAV control MAbs are previously described antibodies TRL053 and TRL579 (15).