TABLE 1

Baseline characteristics of patients infected with M. abscessus belonging to CLA-resistant and -sensitive genotypes

CharacteristicaValuebP value
CLA-resistant group (n = 69)CLA-sensitive group (n = 31)
Median age (IQR) (yr)58 (44–66)56 (32–64)0.562
Males26 (37.7)17 (54.8)0.107
BMI (mean ± SD) (kg/m2)19.93 ± 0.3719.69 ± 0.570.729
Underlying disease
    Prior tuberculosisc29 (42.0)16 (51.6)0.373
    COPD1 (1.4)2 (6.5)0.226
    Hypertension11 (15.9)3 (9.7)0.601
    Diabetes2 (2.9)4 (12.9)0.135
    CHD4 (5.8)0 (0)0.414
    Malignancy3 (4.3)0 (0)0.550
History of surgery3 (4.3)1 (3.2)1
Symptoms
    Cough55 (79.7)25 (80.6)0.914
    Sputum69 (100.0)31 (100.0)1
    Fever15 (21.7)4 (12.9)0.298
    Hemoptysis22 (31.9)4 (12.9)0.045
Radiographic features
    Extent0.404
        Bilateral involvement58 (84.0)28 (90.3)
        Unilateral involvement11 (15.9)3 (9.7)
    Median no. of lobes (IQR)4 (3–6)4 (2–6)0.419
    Disease pattern
        Bronchiectasis66 (95.7)29 (93.4)0.655
        Cavity50 (72.5)8 (25.8)<0.001
        Nodules (diam < 1 cm)38 (55.0)19 (61.3)0.561
        Nodules (diam > 1 cm)39 (56.5)16 (51.6)0.648
        Tree-in-bud pattern16 (23.2)14 (45.2)0.027
Initial AFB smear positivity28 (40.6)10 (32.3)0.428
Initial morphotype0.770
    Rough40 (58.0)17 (54.8)
    Smooth29 (42.0)14 (45.2)
  • a COPD, chronic obstructive pulmonary disease; CHD, coronary heart disease; AFB, acid-fast bacilli; IQR, interquartile range.

  • b Data are the numbers (%) of patients found in the CLA-resistant and -sensitive genotype groups unless otherwise indicated.

  • c Patients treated for tuberculosis prior to the diagnosis of M. abscessus lung disease.