TABLE 4

MFCs of θ-defensins and clinical antifungalsa

Candida CDC strainMFC (μg/ml)CDC phenotype
RTDBTDFlucoCaspo
RTD-1RTD-2BTD-2BTD-4BTD-8CaspoFluco
C. glabrata 03146.253.1253.12512.56.251281RR
C. glabrata 03166.253.1251.5612.56.2582RSDD
C. parapsilosis 03356.256.253.125>256.25161IR
C. parapsilosis 03376.256.253.125256.251281SR
C. tropicalis 03453.1251.561.56251.56>2560.125SR
C. krusei 03973.1253.1251.5612.53.1252561SR
C. auris 038412.56.256.25>256.25>256>8NANA
C. auris 038912.56.256.25>256.25>256>8NANA
  • a MFC assays were conducted as described in Materials and Methods. MFC values correspond to 99% killing relative to input inoculum. Abbreviations are the same as listed in Table 3.