TABLE 1

MICs of θ-defensins and clinical antifungalsa

ATCC strainMIC (μg/ml)ATCC phenotype
RTDBTDAmp BFluco
RTD-1RTD-2RTD-3RTD-4RTD-5BTD-1BTD-2BTD-3BTD-4BTD-5BTD-7BTD-8BTD-9BTD-10EchinTriazole5-Flu
ATCC 641246.256.2512.512.512.56.256.2512.5256.2512.56.2512.56.252>256RRI
ATCC 102316.256.2512.512.512.512.53.12512.5256.2512.56.2512.56.2528RRS
ATCC 28121252512.512.512.52512.5252512.512.56.2512.56.2541SRS
ATCC MYA-287612.52512.512.5252512.512.52512.52512.512.512.5464SSS
ATCC MYA-42712.512.52525252512.5252512.52512.52512.54128SRS
ATCC MYA-5746.256.2512.512.512.56.253.12512.5256.2512.53.12512.53.1252>256SRS
ATCC 908196.256.2512.512.512.56.253.12512.5256.2512.56.2512.56.252>256SRS
ATCC MYA-102312.56.252512.512.512.56.25252512.512.512.512.56.25232SRS
ATCC 7648512.56.2512.512.512.512.51.56252512.512.56.2512.56.252128RSS
ATCC 3828912.512.525252512.512.5252512.52512.5256.254>256SRS
ATCC 1165112.512.525252512.56.25252512.52512.512.512.54>256SRS
ATCC 9690112.56.25252525256.25252512.525252512.541SRS
ATCC 9002912.512.512.52512.512.56.2512.52512.512.512.512.512.541SSR
ATCC 188046.256.2512.512.52512.56.25252512.512.512.512.56.2521SSS
  • a CLSI protocol was used to determine MICs for each θ-defensin and amphotericin B (Amp B) and fluconazole (Fluco). ATCC phenotypes (S, susceptible; R, resistant; I, intermediate) are reported for one or more echinocandin (Echin), triazole, or 5-flucytosine (5-Flu).