TABLE 2

Pharmacokinetic parameters of VT-1129 in uninfected male CD-1 mice after single oral administration of doses of 10 and 100 mg/kg

Pharmacokinetic parametera10 mg/kg VT-1129100 mg/kg VT-1129
PlasmaBrainPlasmaBrain
Cmax3.33 μg/ml5.24 μg/g30.8 μg/ml42.7 μg/g
AUC0–96252 μg · h/ml360 μg · h/g2,602 μg · h/ml3,231 μg · h/g
  • a Cmax and AUC0–96 values were calculated with the mean concentrations from 3 mice at each time point.