TABLE 4

Exposure-response relationships between anti-TB drugs and time to culture conversion, in adjusted models, by diabetes status

CharacteristicNo diabetesDiabetes
aHR95% CIP valueaHR95% CIP value
Age0.990.97, 1.000.070.980.96, 1.00.04
Sex1.781.20, 2.650.0041.690.81, 3.540.17
Wt1.021.0, 1.040.11.00.98, 1.010.73
Baseline bacterial burden1.411.09, 1.840.011.381.06, 1.780.02
Rifampin Cmax1.000.95, 1.050.991.051.03, 1.09<0.001
Isoniazid Cmax1.000.96, 1.050.961.081.04, 1.12<0.001
Pyrazinamide Cmax1.00.98, 1.000.550.960.95, 0.98<0.001