TABLE 3

Pharmacokinetic parameters of VT-1129 in uninfected male CD-1 mice after oral administration of a 30-mg/kg loading dose on day 1 and 5-mg/kg maintenance doses on days 2 to 8

Pharmacokinetic parameteraDay 1, plasmaDay 8
PlasmaBrain
Cmax6.83 μg/ml11.6 μg/ml46.9 μg/g
AUC0–24134 μg · h/ml251 μg · h/ml1,040 μg · h/g
  • a Cmax and AUC0–24 values were calculated with the mean concentrations from 3 mice at each time point.