TABLE 1

Activities of antibiotics against B. burgdorferi B31 and N40

Antibiotic nameMIC (μg/ml)aTargetDrug class
B31N40
Doxycycline0.250.25RibosomeTetracycline
Amoxicillin0.060.06Penicillin-binding proteinsβ-Lactam
Ceftriaxone0.030.12Penicillin-binding proteinsβ-Lactam
Vancomycin0.250.25d-Ala-d-AlaGlycopeptide
Telavancin3232d-Ala-d-AlaLipoglycopeptide
Dalbavancin6464d-Ala-d-AlaLipoglycopeptide
Fosfomycin>50>50MurANovel class
d-Cycloserine6432d-Ala-d-Ala synthesisd-Alanine analogue
Tunicamycin32>64Synthesis of lipid disaccharide intermediateNucleoside antibiotics
Bacitracin3264Undecaprenyl pyrophosphateCyclic peptides
  • a MICs are the mode values.