TABLE 2

Survival of Erdman strain of M. tuberculosis inside THP-1 macrophagesa

Infection status and treatmentNo. of CFU/ml
M. tuberculosis infected46,884 ± 7,255
M. tuberculosis infected plus treatment with:
    NAC26,520 ± 4,496*
    INH2.5 ± 1.306###
    INH + NAC0 ± 0###
    RIF194.2 ± 61.86###
    RIF + NAC22.5 ± 8.269*, ###
    EMB888.3 ± 117.2###
    EMB + NAC215.8 ± 28.75***, ###
    PZA15 ± 3.371###
    PZA + NAC1.667 ± 1.124**, ###
  • a The data represent the mean number of CFU per milliliter plus or minus the standard error for each infection category. *, P < 0.05 when the group treated with antibiotic plus NAC is compared to the group treated with antibiotic alone or the infected group treated with NAC is compared to the infected control group; **, P < 0.005 when the group treated with antibiotic plus NAC is compared to the group treated with antibiotic alone or the infected group treated with NAC is compared to the infected control group; ***, P < 0.0005 when the group treated with antibiotic plus NAC is compared to the group treated with antibiotic alone or the infected group treated with NAC is compared to the infected control group; #, P < 0.05 when the group treated with each antibiotic is compared to the infected control group; ##, P < 0.005 when the group treated with each antibiotic is compared to the infected control group; ###, P < 0.0005 when the group treated with each antibiotic is compared to the infected control group.