TABLE 2

B. burgdorferi N40 cultures from skin and DNA copies from bladder of both wild-type and SCID mice after 5 days of treatmenta

WT treatment groupWhole-ear culture resultbNo. of bladder DNA copiesc
WT
    Saline+40
+25
+20
+32
+105
+53
    Doxycycline0
0
0
0
0
0
    Ceftriaxone0
0
0
0
0
0
    Vancomycin0
0
0
0
0
0
SCID
    Saline+609
+1,032
+1,043
+1,667
+1,776
+1,327
    Doxycycline+7
+9
+9
6
0
+4
    Ceftriaxone0
0
0
0
0
0
    Vancomycin0
0
0
0
0
0
  • a The following doses were given every 12 h for 5 days: doxycycline, 50 mg/kg; ceftriaxone, 156 mg/kg; and vancomycin, 110 mg/kg.

  • b +, B. burgdorferi cells were detected in the culture; −, no B. burgdorferi cells were detected in the culture.

  • c DNA copies were normalized to 200 ng of tissue DNA.