TABLE 2

Potency of quinoline inhibitors in the presence of seruma

CompoundMIC against E. coli CFT073 ΔtolC (μg/ml)
No serum10% mouse serum
G59218 ± 5>41
G913<0.22 ± 0.155.6 ± 3.9
G3320.31 ± 0.224.2 ± 1.6
  • a For all samples, n ≥ 3. The plasma protein binding level for all compounds was 99%.