TABLE 1

Plasma and brain concentrations of VT-1129 in uninfected male CD-1 mice after single oral administration of VT-1129 at 10 and 100 mg/kg (n = 3 per time point)

Time (h)10 mg/kg VT-1129100 mg/kg VT-1129
Plasma level (mean ± SD) (μg/ml)Brain level (mean ± SD) (μg/g)Brain/plasma ratioPlasma level (mean ± SD) (μg/ml)Brain level (mean ± SD) (μg/g)Brain/plasma ratio
0.250.486 ± 0.1550.351 ± 0.0560.75.827 ± 1.0983.759 ± 0.3740.6
0.51.024 ± 0.1311.405 ± 0.3021.47.944 ± 2.13210.974 ± 3.3911.4
11.783 ± 0.1922.927 ± 0.2051.613.122 ± 0.79423.552 ± 3.3531.8
22.088 ± 0.2235.241 ± 1.7702.514.933 ± 2.12434.531 ± 3.9052.3
42.832 ± 0.7744.616 ± 0.3531.618.315 ± 2.32535.911 ± 1.2142.0
62.996 ± 0.2775.109 ± 0.0841.715.964 ± 1.57042.686 ± 6.6032.7
243.329 ± 0.9084.365 ± 0.1091.330.608 ± 2.36140.346 ± 1.4841.3
482.562 ± 0.3933.888 ± 0.2911.530.787 ± 4.55131.936 ± 8.6581.0
962.057 ± 0.2082.401 ± 0.2441.225.742 ± 2.93427.624 ± 3.2631.1
Average1.431.57