TABLE 5

MICs of G332 on multidrug-resistant strainsa

SpeciesStrainKnown acquired resistancebG332 MIC (μg/ml)
E. coliCDC 0006KPC+, NDM2.8 ± 0
CDC 0055KPC, NDM2.8 ± 0
CDC 0061NDM4.5 ± 1.6
CDC 0001KPC-3, TEM-15.9 ± 0
K. pneumoniaeCDC 0079NDM2.8 ± 0
CDC 0106KPC-3, TEM-12.8 ± 0
E. cloacaeCDC 0053CTX-M14, DHA-1, OmpF/OmpK355.9 ± 0
CDC 0038NDM5.9 ± 0
  • a For all samples, n ≥ 3.

  • b KPC+, strain contains a Klebsiella pneumoniae carbapenemase (KPC); KPC, strain does not contain a KPC; NDM, strain does not contain a New Delhi metallo-β-lactamase (NDM).