TABLE 1

In vitro activity against OXA-48 producers

DrugReference(s)Total no. of isolates tested across all studiesMIC (mg/liter)% susceptible
50%90%Range
Ceftazidime18, 21, 23, 26, 33, 35, 36, 37, 62, 706740.12 to 256128 to 5120.06 to 5128 to 40
Cefepime18, 21, 22, 26, 46, 50, 702420.25 to 3216 to 5120.12 to >5120 to 46
Aztreonam18, 33, 35, 36, 37, 70599128128 to >512<0.015 to >51212.2 to 27
Meropenem18, 26, 35, 3640, 50, 62, 717340.06 to 1280.25 to 2562 to 2560 to 87.8
Doripenem18, 26, 70170>40.5 to >40.25 to >410 to 83.3
Ertapenem18, 26, 35, 36373>11 to >8>10 to 4.1
Imipenem18, 23, 26, 35, 36, 727810.12 to 328 to 2561 to 2560 to 74.8
Levofloxacin18, 70140>4>40.03 to >40 to 20.9
Amdinocillin3314a43
Plazomicin (ACHN-490)73, 7419<0.12 to 64<0.12 to 64
Amikacin18, 26, 35, 36, 37, 736281 to 82 to >640.5 to >6436.7 to 100
Gentamicin73190.25 to 1280.25 to >12868
Colistin18, 26, 3436, 38520<0.12 to 0.251 to 1280.015 to 12875.4 to 100
Tigecycline18, 26, 35, 36386490.25 to 120.12 to 836 to 91
Fosfomycin35, 3628144.8 to 82
Piperacillin-tazobactam18, 62, 70155128128 to 25632 to 2560
Ceftazidime-avibactam18, 19, 21, 23, 33, 37, 627050.03 to 10.5 to 256<0.008 to 25680 to 100
Cefepime-avibactam21260.016 to 0.120.5<0.008 to 0.5100
Cefepime-zidebactam2215<0.03100
Cefepime-tazobactam46251 to 81 to 880
Imipenem-avibactam21260.016 to 0.50.5<0.008 to 2100
Imipenem-relebactam2341 to 81 to 825
Aztreonam-avibactam24, 33710.12 to 0.250.25 to 10.12 to 1100
Meropenem-vaborbactam39, 716216≥320.12 to >320 to 3.8
Ceftolozane-tazobactam19, 47211 to >256>2560.5 to >25613 to 50
Cefiderocol (S-649266)5060.2520.125 to 2
Meropenem–CB-6184020.25 to 0.50.25 to 0.5
  • a —, data not available.