Parameter | Geometric mean value for study group (95% CI) | Geometric mean ratio (95% CI) (P value) | |||
---|---|---|---|---|---|

ART naive (n = 10) | LPV/r (n = 15) | EFV (n = 15) | LPV/r/ART naive | EFV/ART naive | |

AUC_{0–14 days} (h · μg/ml) | 1,084 (760–1,547) | 2,107 (1,654–2,686) | 1,081 (816–1,432) | 1.94 (1.26–3.00) (0.004) | 0.99 (0.63–1.57) (0.991) |

C_{max} (μg/ml) | 15 (10–23) | 19 (16–23) | 18 (14–23) | 1.27 (0.81–1.93) (0.265) | 1.20 (0.75–1.84) (0.456) |

t_{max} (h) | 66 (24–72) | 72 (60–72) | 48 (12–72) | 0.145^{b} | 0.340^{b} |

t_{1/2} (h) | 160 (103–248) | 190 (154–236) | 102 (61–170) | 1.19 (0.73–1.94) (0.438) | 0.64 (0.32–1.26) (0.217) |

C_{d7} (μg/ml) | 1 (0.9–2) | 4 (3–6) | 0.5 (0.3–0.8) | 4.00 (1.72–5.39) (<0.001) | 0.50 (0.21–0.74) (0.009) |

↵a PK parameters are presented as geometric means (95% confidence intervals), except for

*t*_{max}values, which are presented as medians (interquartile ranges).*P*values were calculated using analysis of variance in Stata 15.0 (α = 0.05).*C*_{d7}, day 7 plasma lumefantrine concentration.↵b

*P*value only, calculated using the Wilcoxon rank sum test (α = 0.05).