TABLE 3

Susceptibility of E. coli expressing E. coli or A. baumannii MsbA

CompoundaMIC (μg/ml)b
pEcMsbApAbMsbA
G59220 ± 0>41
G9130.94 ± 0.41>45
G3320.27 ± 0.1032 ± 23
CIP0.006 ± 00.012 ± 0
PMB0.11 ± 0.0380.16 ± 0.080
TET0.69 ± 00.69 ± 0
ERM0.05 ± 00.10 ± 0
  • a CIP, ciprofloxacin; PMB, polymyxin B; TET, tetracycline; ERM, erythromycin.

  • b For all samples, n ≥ 3. MICs were determined for E. coli MG1655 msbA-cKO lptD(imp4213) carrying a plasmid expressing either E. coli MsbA (pEcMsbA) or A. baumannii MsbA (pAbMsbA).