TABLE 3

ETX2514 concentrations and ratios of ELF or AM to unbound plasma concentration at BAL fluid sampling timesa

Sampling time (h)bETX2514 concentration (mg/liter) in:Ratio of ETX2514c
Plasma (total)ELFAMELF to plasma (unbound)AM to plasma (unbound)
124.33 ± 3.359.14 ± 1.511.89 ± 0.870.42 ± 0.040.09 ± 0.04
2.531.23 ± 3.8010.47 ± 1.700.95 ± 0.680.37 ± 0.020.04 ± 0.03
3.2520.78 ± 4.547.14 ± 1.662.09 ± 3.180.38 ± 0.040.12 ± 0.21
415.10 ± 2.686.03 ± 1.880.94 ± 0.47d0.45 ± 0.110.07 ± 0.03d
65.33 ± 1.802.15 ± 0.781.21 ± 0.910.46 ± 0.110.32 ± 0.38
  • a Data are expressed as means ± SDs.

  • b Six subjects per sampling period.

  • c The unbound fraction of ETX2514 in plasma was assumed to be 0.90.

  • d Value reflects the mean ± SD from 5 samples.