Parameter^{a} | Adult (%RSE^{b}) (n = 24) | Child (n = 23) |
---|---|---|

CL (10^{12} cells/h) | 454 (9) | 230 |

V_{c} (10^{12} cells) | 2,569 (18) | 1,037 |

Q (10^{12} cells/h) | 469 (30) | 238 |

V_{p} (10^{12} cells) | 7,500 (58) | 3,027 |

k_{a} (1/h) | 1.17^{c} (46) | |

F | 1 (fixed) | |

Additive error (fmol/10^{6} cells) | 0.6 (fixed)^{d} | |

Proportional error (%) | 27.4 (8) | |

IIV CL (%CV) | 30.4 (21) | |

IOV F (%CV) | 36.2 (20) | |

IOV k_{a} (%CV) | 30.6 (61) |

↵a All clearance and volume of distribution parameters were estimated by allometric scaling using fat-free mass, and the typical values reported here refer to an adult with a median fat-free mass of 47.2 kg. The children values are also reported here for comparison, but they were not estimated separately in the model; they were just obtained by rescaling the adult values to the median fat-free mass of our children cohort, 19.1 kg. IIV and IOV were assumed to be log-normally distributed, and their magnitudes are reported here as approximate coefficient of variation (%CV). CL, apparent oral clearance;

*V*_{c}, apparent central volume of distribution; Q, apparent oral intercompartmental clearance;*V*_{p}, apparent peripheral volume of distribution;*k*_{a}, appearance rate constant;*F*, bioavailability, IIV, interindividual variability; IOV, interoccasion variability.↵b RSE, relative standard error.

↵c A Bayesian prior with values from Horton et al. (18) was used for the estimation of

*k*_{a}.↵d The estimate of the additive error was small and not stable, so it was fixed to 20% of the median LLOQ.