Effect of neuraminidase mutation on IC50 and enzyme kinetics
Virus | Mean ± SD (fold difference)a | ||||
---|---|---|---|---|---|
IC50 (nM) for: | Km (μM) | ||||
Zanamivir | Oseltamivir | Laninamivir | Peramivir | ||
WT-H273 | 2.2 ± 1.3 | 36.1 ± 5.4 | 2.6 ± 2.0 | 1.0 ± 0.05 | 11.5 ± 1.5 |
Mut-Y273 | 1.4 ± 0.5 (1) | 96.7 ± 10.8 (3) | 1.63 ± 0.4 (1) | 80.9 ± 6.8 (85)b | 12.3 ± 0.8 (1) |
WT-D197 | 1.6 ± 0.2 | 35.1 ± 3.3 | 2.8 ± 1.3 | 1.0 ± 0.1 | 13.8 ± 1.3 |
Mut-N197 | 4.5 ± 0.7 (3) | 66.2 ± 7.5 (2) | 5.0 ± 1.2 (2) | 3.0 ± 0.7 (3) | 30.3 ± 3.3 (3) |