TABLE 3

Stavudine dosing guidelines shown by number of capsules or milliliters by weight band twice daily for children >2 years

Body wt (kg)WHO guideline, target 1 mg/kg twice dailyNew proposed guideline, target 0.5–0.75 mg/kg twice dailya
7–9.9 (>2 years old)9 ml (9 mg)b7.5 ml (7.5 mg) or open 15-mg capsule into 5 ml water; give 2.5 mlb
10–13.91 capsule (15 mg)10 ml (10 mg) or open 20-mg capsule into 5 ml water; give 2.5 mlb
14–16.91 capsule (20 mg)1 (15 mg), 15 ml or open 15-mg capsule into 5 ml waterb
17–19.91 capsule (20 mg)1 (15 mg), 15 ml or open 15-mg capsule into 5 ml waterb
20–24.91 capsule (20 mg)1 capsule (15 mg)
25–29.91 capsule (30 mg)1 capsule (20 mg)
30–59.91 capsule (30 mg)1 capsule (20 mg)
>601 capsule (30 mg)1 capsule (30 mg)
  • a Doses were rounded off to fall into a stavudine dose range of 0.5 to 0.75 mg/kg twice daily based on the current available capsules (15, 20, and 30 mg) and liquid formulation (1 mg/ml) strengths.

  • b The proprietary liquid formulation requires refrigeration. For patients who do not have access to a refrigerator, an adult capsule may be opened and dispersed in water.