TABLE 2

Stasis and 1-log kill doses and associated AUC/MIC (total and free-drug) values in the neutropenic murine disseminated candidiasis modela

StrainMIC (mg/liter)Stasis1-log kill
Dose (mg/kg)Ave 24-h tAUC/MICAve 24-h fAUC/MICDose (mg/kg)Ave 24-h tAUC/MICAve 24-h fAUC/MIC
B112200.060.87144.781.166.99987.687.90
B117850.1256.09421.393.410.65685.805.49
B117990.258.76288.722.316.17488.813.91
B11211223.0482.950.66NA
Mean9.69234.461.8811.27720.765.77
Median7.43216.751.7310.65685.805.49
SD9.48151.531.214.62251.262.01
  • a Ave, average; tAUC/MIC, total-drug AUC/MIC; fAUC/MIC, free-drug AUC/MIC; NA, not achieved.