TABLE 4

B. burgdorferi N40 cultures from skin and DNA copies from tissues of SCID mice after one or two doses of 110 mg/kg vancomycin or 156 mg/kg ceftriaxonea

Treatment groupWhole-ear culture resultbNo. of DNA copies inc:
SpleenBladderHeart
Ceftriaxone, 1 dose1438309
+55870132
+030136
+7211177
+3856189
+3880099
461480
Ceftriaxone, 2 doses2426182
+38236895
481310
488096
9580131
00204
121248
Vancomycin, 1 dose5300
000
000
+1215258
+5104128
+2297370
91214
Vancomycin, 2 doses3500
0044
+13848367
000
000
02660
671040
  • a Mice were sacrificed 24 h after the second dose.

  • b +, B. burgdorferi cells were detected in the culture; −, no B. burgdorferi cells were detected in the culture.

  • c DNA copies were normalized to 200 ng of tissue DNA.