TABLE 4

Sulbactam concentrations and ratios of ELF or AM to unbound plasma concentration at BAL fluid sampling timesa

Sampling time (h)bSulbactam concentration (mg/liter) in:Ratio of sulbactamc
Plasma (total)ELFAMELF to plasma (unbound)AM to plasma (unbound)
117.28 ± 2.979.22 ± 2.252.30 ± 0.790.81 ± 0.140.21 ± 0.09
2.521.42 ± 3.3110.25 ± 2.291.41 ± 0.770.73 ± 0.160.11 ± 0.07
3.2512.03 ± 2.665.67 ± 1.742.18 ± 2.940.72 ± 0.140.26 ± 0.34
48.58 ± 1.904.64 ± 1.561.31 ± 0.53d0.83 ± 0.250.21 ± 0.11d
62.24 ± 1.011.27 ± 0.491.16 ± 0.800.94 ± 0.421.22 ± 1.63
  • a Data are expressed as means ± SDs.

  • b Six subjects per sampling period.

  • c The unbound fraction of sulbactam in plasma was assumed to be 0.62.

  • d Value reflects the mean ± SD from 5 samples.