TABLE 1

Free fraction of NVR 3-778 in different hepatocyte cultivation media and in human plasma

Culture mediumaFree fraction (%)b
no BSA, no hA1GP72.9 ± 1.9
4.3% BSA + 0.07% hA1GP9.7 ± 0.5
8% BSA + 0.07% hA1GP6.4 ± 0.1
hPlasma1–2
  • a Hepatocyte cultivation medium (HCM) was incubated with 1 μM NVR 3-778 while human plasma (hPlasma) was incubated with concentrations ranging from 0.1 to 10 μM.

  • b Data represent mean values of three replicates ± SEM.