TABLE 6

LSSs of levofloxacin using multiple linear regression

Maximum time span (h)Sampling time point (h)AUC0–24,est calculationnr2MPE (%)RMSE (%)
1st2nd3rd
8065.71 + 35.59 × C0300.84914.818.5
84−22.43 + 16.51 × C4300.89211.215.6
88−16.40 + 21.93 × C8100.9962.63.1
70227.84 + 23.87 × C0 + 5.50 × C2300.9239.112.9
717−5.43 + 3.00 × C1 + 13.88 × C7200.9395.97.1
7044.96 + 18.12 × C0 + 10.04 × C4300.9775.57.0
828−18.79 + 0.99 × C2 + 20.60 × C8100.9962.52.9
8080.11 + 6.48 × C0 + 18.05 × C8100.9972.22.5
848−4.28-4.76 × C4 + 26.98 × C8100.9972.12.5
7027−3.01 + 10.58 × C0 + 2.91 × C2 + 11.31 × C7200.9793.04.1
7037−2.98 + 10.69 × C0 + 3.99 × C3 + 10.18 × C7200.9862.63.3
70473.10 + 11.79 × C0 + 5.63 × C4 + 7.12 × C7200.9872.23.2
8128−16.34-1.33 × C1 + 2.11 × C2 + 21.05 × C8100.9971.82.3
8248−6.51 + 1.04 × C2 − 4.87 × C4 + 25.70 × C8100.9971.82.1
8028= 1.18 + 8.35 × C0 + 1.53 × C2 + 14.86 × C8100.9971.41.7