TABLE 1

Subject demographic and baseline characteristicsa

CharacteristicNormal renal
function (n = 6)
Mild renal
impairment (n = 6)
Moderate renal
impairment (n = 6)
Severe renal
impairment (n = 6)
Total (N = 24)
Age (yr)61.8 ± 8.0862.7 ± 7.5565.7 ± 9.2765.3 ± 7.2863.9 ± 7.73
Female (no. [%])3 (50.0)2 (33.3)3 (50.0)4 (66.7)12 (50.0)
White (no. [%])5 (83.3)5 (83.3)5 (83.3)4 (66.7)19 (79.2)
Wt (mean ± SD) (kg)83.1 ± 14.772.4 ± 8.577.7 ± 11.174.1 ± 21.576.8 ± 14.4
BMI (mean ± SD) (kg/m2)28.1 ± 3.9325.7 ± 2.4127.4 ± 2.4027.4 ± 3.8927.2 ± 3.15
CLCR (mean ± SD) (ml/min)115 ± 18.575.9 ± 5.0249.5 ± 8.0521.2 ± 6.9565.5 ± 36.9
  • a BMI, body mass index; CLCR, creatinine clearance; Wt, weight.