TABLE 2

Comparison of pharmacokinetic parameters of the sulfoxide and its sulfone metabolite following oral administration of 1.5 mg kg−1 sulfoxidea

Mouse strainCmax
(µg ml–1)
Tmax(h) AUC(0–48)
(µg h ml–1)
Sulfoxide
AUC(0–48)
(µg h ml–1)
Sulfone
Ratio AUC(0–t)
Sulfone/sulfoxide
C57BL/60.10410.2217.0832.0
Healthy NSG0.053710.1537.0045.8
Infected NSG0.032110.1656.6440.0
  • a AUC(0–48), AUC from time 0 to 48h; AUC(0–t), AUC from time 0 to time t.