TABLE 4

Pharmacokinetic parameters

PK parameterValue for:RatioP valuea
DBS
(mean ± SD, n = 3)
Plasma
(mean ± SD, n = 3)
Cmax (μg · ml−1)2.070 ± 0.4791.937 ± 0.2251.070.4729
Tmax (h)2.83 ± 1.162.67 ± 1.441.060.4226
kel (h−1)0.041 ± 0.0170.056 ± 0.0080.740.2458
t1/2 (h)19.38 ± 9.9412.62 ± 1.801.540.3478
AUC0-t (μg · ml−1 · h−1)26.623 ± 2.88032.838 ± 5.1160.810.0617
AUC0–∞ (μg · ml−1 · h−1)33.691 ± 7.88935.885 ± 6.4990.940.7007
  • a P values were determined by two-tailed, paired t test, with 99% confidence intervals (GraphPad Prism, v. 5.03).