TABLE 1

Baseline subject demographics

DemographicStudy finding
Single doseaSingle-dose PKFood effect
(400 mg [n = 24])
Multiple-dose PK
(400 mg [n = 12])
Effect on thorough QT/QTc interval (n = 46)
Active group
(n = 52)
Placebo group
(n = 20)
300 mg
(n = 12)
400 mg
(n = 12)
600 mg
(n = 12)
Placebo
(n = 11)
400 mg chinfloxacin
(n = 11)
600 mg chinfloxacin
(n = 12)
400 mg moxifloxacin
(n = 12)
Age, yr (range)28 (20∼41)28 (18∼40)25 (20∼37)29 (25∼36)26 (22∼37)27 (20∼40)27 (21∼36)28 (20∼36)33 (25∼40)30 (22∼37)30 (24∼37)
Gender, no. male/no.
female
26/2610/106/66/66/612/1212/125/65/66/66/6
Weight, kg62 ± 661 ± 560 ± 660 ± 860 ± 860 ± 760 ± 761 ± 7
Height, cm (means ± SD)166 ± 7167 ± 7165 ± 5166 ± 8167 ± 8164 ± 8170 ± 8165 ± 8163 ± 8168 ± 7166 ± 8
BMI, kg/m2 (means ± SD)22.2 ± 1.321.9 ± 1.522.0 ± 1.321.7 ± 1.321.6 ± 1.422.1 ± 1.221.6 ± 1.022.5 ± 1.522.6 ± 1.522.9 ± 1.422.4 ± 0.8
  • a Subjects in the active group of the single-dose study received 50, 100, 300, 400, 600, or 800 mg of drug.