Parameter^{a} | Mean | Median | Standard deviation |
---|---|---|---|

V (liters) | 359.4 | 366.6 | 34.37 |

CL (liters/h) | 19.96 | 20.01 | 0.7932 |

K_{g-s} (h^{−1}) | 0.1310 | 0.1663 | 0.04998 |

K_{g-r} (h^{−1}) | 0.1286 | 0.1268 | 0.01349 |

K_{kill-s} (h^{−1}) | 1.786 | 1.728 | 0.2493 |

K_{kill-r} (h^{−1}) | 0.9252 | 1.098 | 0.6398 |

C_{50-s} (mg/liter) | 12.19 | 12.98 | 1.924 |

C_{50-r} (mg/liter) | 12.85 | 12.52 | 0.9446 |

H_{s}^{b} | 13.08 | 11.33 | 3.876 |

H_{r}^{b} | 12.94 | 18.76 | 7.880 |

POPMAX (CFU/ml) | 2.357 × 10^{8} | 1.492 × 10^{7} | 2.760 × 10^{8} |

K_{nat-death-s} (h^{−1}) | 0.1512 | 0.1876 | 0.04798 |

K_{nat-death-r} (h^{−1}) | 0.1585 | 0.1656 | 0.01431 |

IC_{2} (CFU/ml) | 3.131 × 10^{6} | 3.024 × 10^{6} | 1.980 × 10^{5} |

IC_{3} (CFU/ml) | 7.431 | 6.085 | 2.165 |

↵a

*V*, volume of distribution; CL, clearance; s, susceptible subpopulation; r, resistant subpopulation;*K*_{g}, first-order growth rate constant;*K*_{kill}, first-order kill rate constant;*C*_{50}, moxifloxacin concentration at which the kill rate is half-maximal;*H*, Hill constant; POPMAX, maximal bacterial concentration;*K*_{nat-death}, first-order kill rate constant independent of moxifloxacin concentration; IC_{2}, initial condition of total*M. tuberculosis*population; IC_{3}, initial condition of resistant*M. tuberculosis*population.↵b Unitless.